Introduction: The aim of this study was to consider the cognitive emotion regulation strategies, neuroticism and extravertion with obsession- compulsion symptoms in non- clinical people.Methods: The present study was a descriptive- causal study. 400 students from Tabriz University were selected by multistage clustering. The Cognitive emotion regulation questionnaire, Neo-FFI personality inventory, and the Maudzly questionnaire were completed by students.Results: Path- analysis were used for analyzing the data. Results showed that positive reappraisal, refocusing on planning, and extraversion perspective-taking changed the obsession-compulsion symptoms in mediation negatively. Also, self-blame and extraversion rumination changed the obsession-compulsion symptoms in mediation positively.In addition self -blame, rumination, catastrophizing through neuroticism changed obsession- compulsion symptoms in mediation of neuroticism positively. Acceptance strategies, positive reappraisal, positive refocusing, refocusing on planning, and extraversion perspective-taking changed obsession- compulsion symptoms in mediation of neuroticism negatively.Conclusion: These findings indicated that cognitive emotion regulation strategies with a mediator of extraversion and neuroticism can be predicted as obsession- compulsion symptoms. These findings have empirical implication in clinical interventions.