Introduction: New psychological and neuropsychological studies have shown that the symptom and sign orientation approach is more useful in understanding the nature of schizophrenia. The aim of the present study was to investigate the relationship between spatial-temporal integration and positive and negative symptoms in patients with schizophrenia. Method: Fifty patients with schizophrenia were examined with a spatial-temporal integration task. Results: There were negative correlation between spatial-temporal integration ability and positive-negative symptoms. Conclusion: By decreasing spatial-temporal integration ability the positive-negative symptoms increases in patients with schizophrenia.