Introduction: This paper investigates the relationships between extraversion, neuroticism and psychoticism dimensions with brain / behavioral systems.Methods: Randomly selected 128 female university students in Tehran completed Gray-Wilson Personality Questionnaire and Eysenck Personality Questionnaire-Reversion, using Pearson Correlation Coefficiency and Regression analysis, .Result: The results showed that extraversion and behavioral activation systems had no significant correlation while the correlation of extraversion with behavioral activation systems was negatively significant. Neuroticism had a positive correlation with both behavioral inhibition system and fight/flight system. Psychoticism was related to several components of Gray's model: it was positively related to approach, passive avoidance, fight and flight, while its correlation with active avoidance was negatively significant.Conclusion: The results of regression analysis indicated that neuroticism was a good predictor of behavioral inhibition system.