Introduction: Because physical-motor disabilities can lead to several emotional and mental problems, it is necessary to use solutions to reduce or alleviate such problems. Therefore, the purpose of this research was to determine the effectiveness of life skills training on anxiety, happiness, and anger control in adolescents with physical-motor disabilities.Method: The subjects of this study included adolescents with physical-motor disabilities whose school was randomly selected out of three available schools in Isfahan. Thirty subjects were randomly selected from the students of that school. They were then divided into two groups: experimental and control groups. The tools used in this research were the Aggression Questionnaire and the Piers-Harris Questionnaire. A pre-test was administered to both experimental and control groups. Then, the experimental group was subjected to life skills training. A post-test was administered to both groups at the end of the training.Results: The results of the covariance analysis showed that there were significant differences between the mean scores of anxiety, happiness, and anger control in the experimental and control groups on the post-test.Conclusion: These findings recommend that life skills training is used to reduce anxiety, control anger, and increase happiness in physical-motor disabled adolescents.