Introduction: This study was designed to investigate the effectiveness of cognitive behavioral intervention on coping responses and cognitive emotion regulation strategies in women. Method: This study is a quasi- experimental with pretest posttest and follow up design. 58 employees of AL-Zahra university were randomly selected and assigned to two experimental and waiting list groups (n=29). 12 three-hours sessions of cognitive behavioral treatment were implemented for two groups in different times. Coping Responses Inventory, and Cognitive Emotion Regulation questionnaire were used for collecting data. Data were analyzed using independent T-test, covariance analysis, repeated measure. Results: cognitive behavioral intervention showed a significant difference in the scales of coping responses and cognitive emotion regulation strategies in two groups. Also, the changes in three-month follow up was persistent. Conclusion: Cognitive behavioral intervention can positively increase the use of problem oriented coping responses, cognitive strategies focusing on planning,revising and reappraisal in regulating emotions and also can decrease the emotion oriented coping responses, self blame, rumination and catastrophizing cognitive strategies.